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From a mechanistic perspective, chronic iron accumulation creates a permissive environment for ferroptosis by increasing the labile iron pool, promoting lipid peroxidation, and overwhelming antioxidant defense systems such as the GPX4glutathione axis
Romand S, Jostock T, Fornaro M, Schmidt J, Ritter A, Wilms B, Laux H (2016) Improving expression of recombinant human IGF-1 using IGF-1R knockout CHO cell lines
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A global reduction in 5-methylcytosine (5mC) levels, indicative of widespread hypomethylation, has been reported in astrocytes of postmortem AD brains, potentially leading to aberrant gene activation 25
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